Two threads, written separately — what's changing in AI and software, and what's changing in biology and medicine.
Claude Haiku 5.5 and the case for progress without superintelligence, 722 unverified math papers and the experiments-first view of AI for science, subscriptions that eat 40% of compute, and more
OpenAI DevDay 2026 ships a Jev competitor in a week, the Jev classifier saga gets a third chapter, agents get real payment rails and tool gateways, and more
Claude Opus 5.5's price cut disappears at max effort, Xiaomi's MiMo-V2.6-Pro tops the open-weights leaderboard, Epoch AI and SemiAnalysis size up the US-China gap from two different directions, and more
Jev gets cloned six times in two days, Dario Amodei's pacing proposal splits into a cartel fight, AIUC raises $40M to insure agents, OpenAI's own review process becomes an agent too, and more
Looped transformers and where Astra's hidden reasoning comes from, DeepSeek v4.1-Flash's encoder-decoder turn, a Navier-Stokes claim with no theorem attached, Nvidia's backstop math, and more
GPT-6 Astra trades monitorability for capability, Gemini 3.8 Flash and a gated cyber model, Grok Bot's one-click agents, Claude Fable 5.1, Muse Spark 1.3, and more
OpenAI's own chip Jalapeño, NVIDIA buys Hugging Face, GLM 5.3 Flash release, and more
GLM 5.3 and the post-training scaling dial, simulation as the next scaling axis, model routing hits production, and more
A reasoning-trace exfiltration bug, Anthropic watermarks Claude, Gemini 3.7 Flash, Grok 4.6 and Grok Bot, Meta's open-weights return, and more
Qwen 3.8 Max open weights, Kimi K3, a wave of DeepMind departures, AMD buys Taalas, SpaceX's 10GW compute bet, and more
o3-pro, Magistral, Seedance 1.0, reasoning collapse, token entropy, model memorization, fine-tuning, multi-agent systems, and Apple's WWDC.
Also DeepSeek-R1-0528, VoRA, Claude 4 Sonnet's full system prompt, circuit-tracer, Agentic RAG, and Spurious Rewards in MCP GitHub server security.
Also Claude 4, Google I/O, Gemma 3n, AdaptThink, Universal Geometry of Embeddings, MatFormer, and Fusion in IR.
Also Codex-CLI, Intellect-2, Wait Tokens, Untruthful Reasoning Models, Byte Transformers, and Thorium Reactors.
An introduction to the Model Context Protocol and how to put it to use inside a company.
TLDR: processing input tokens is done in parallel, generating output tokens is sequential.
Reranking is a simple, effective technique for improving RAG systems by prioritizing the most relevant retrieved results.
cell-free and shotgun tools that let engineers stop fighting the cell, a gut microbiome that predicts vaccine fever and makes a statin-like molecule, a Nobel for optogenetics, and more
gene editors that work but can't reach the right organ, a new model of aging as cells forgetting their own identity, a WRN helicase inhibitor that controls but rarely cures MSI cancer, and more
Anthropic's AI agents find an uncharacterized CRISPR-like repeat in a giant virus, the largest gene-activity map of the human prefrontal cortex yet made, evorpacept earns its CD47 biomarker in HER2+ gastric cancer, and more
CRISPR traced back to ancient viral warfare, a mouse grown a human cortex in the space where its own used to be, GFH375 hits 35% response rates in pancreatic and lung cancer, and more
AlphaGenome scores all nine billion human variants, a DNA model beats every ESM on phi X174, an AI screening trial that cut 44% of the reading workload, and more
Blood cells take over the ageing brain, in-body CAR-T for MS, a pan-RAS drug spreading across cancers, every mutation in a classic genome, and more
Mitochondria injection against vision loss, neurogenesis's role in depression, SSRIs' unproven record, and more
Moderna's melanoma vaccine works, a narcolepsy drug that treats the cause, a blood-flow microrobot, supercentenarian cancer immunity, and more
A controversial Alzheimer's drainage surgery, glucose-responsive probiotics, tau wrecking neurons' power plants, the brain's midlife cliff, and more
The heart's own 'little brain', brain-organoid computers and their ethics, a universal pneumococcal vaccine, a Neanderthal muscle gene, and more