2 trials tracked · 1 active · last refreshed 2026-08-10
TG4050 is Transgene and NEC's personalized vaccine, built by predicting each patient's tumor-specific mutations with NEC's AI platform and encoding them into a myeloid-derived viral vector — a different delivery approach than the mRNA or peptide vaccines tracked elsewhere here. Its one active trial tests it after surgery in head and neck cancer, alongside standard treatment rather than in place of it.
Its earlier completed trial in ovarian carcinoma was the program's first proof-of-concept — head and neck cancer is now the lead indication being pursued, with ovarian carcinoma not currently in active recruitment despite still showing in the tracked condition list.
Click a row for what it's testing, where, and how many participants.
| NCT ID | Title | Phase | Status | Started | |
|---|---|---|---|---|---|
| ▸ | NCT04183166 | A Clinical Trial Evaluating TG4050 in Head and Neck Cancer | Phase I, Phase II | Active, not recruiting | 2019-12-12 |
This is a multicenter, open-label, two arms, randomized, phase I/II study evaluating the safety and tolerability as well as some activity parameters of TG4050 in patients with squamous cell carcinoma of the head and neck (SCCHN). Enrollment 80 (actual) Sites 14 across 4 countries Countries France, Spain, United Kingdom, United States Sponsor Transgene Primary outcome: Phase I: Safety and tolerability (Adverse Event reported per CTCAE v5) | |||||
| ▸ | NCT03839524 | A Trial Evaluating TG4050 in Ovarian Carcinoma. | Phase I | Completed | 2019-12-09 |
This is a multicenter, open-label, single arm phase I study evaluating the safety and tolerability as well as some activity parameters of TG4050 in patients with ovarian, fallopian or peritoneal serous carcinoma. Enrollment 64 (actual) Sites 6 across 2 countries Countries France, United States Sponsor Transgene Primary outcome: Safety and Tolerability (Adverse Event Reported Per CTCAE v5) | |||||
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